Hawthorn Berries Site:standardprocess.com – Hawthorn has been used since ancient times across continents and medical traditions for its nutritional and medicinal properties. Various parts of the plant including leaves, flowers and berries have been documented for their medicinal effects and have a long traditional use for improving cardiac function and blood circulation.
Hawthorn is among the most important medicinal plants and has been used since ancient times across continents and medical traditions for its nutritional and medicinal properties. Several Hawthorn species have been employed, with
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Most prominent in Western vegetarian traditions. Botanically, Hawthorn is a deciduous tree of the Rose family that is native to Europe and is widely distributed throughout North America and the western parts of Asia. Various parts of the plant including leaves, flowers and berries have been documented for their medicinal effects and have a long traditional use for improving cardiac function and blood circulation.
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Hawthorn’s cardiotonic properties were first recorded in Europe during the late 1800s, and the herb was later introduced into North American medical practice by the Eclectic Physicians during the 19th century.
Hawthorn has traditionally been used to treat conditions such as hypertension, hyperlipidemia, and as an anti-atherosclerotic, antispasmodic and diuretic agent. One of the first references to Hawthorn in scientific research was for its beneficial effects against hypertension in 1939, and since then numerous laboratory and clinical studies have proven its cardiotonic effectiveness, especially when standardized to its polyphenol content. powerful.
The pharmacological effects and chemical constituents of Hawthorn have been extensively researched, and range from amines, terpenoids, and polyphenolics including chlorogenic acid, epicatechin, hyperoside, quercetin, rutin, vitexin, and procyanidins.
In particular, Hawthorn has an excellent content of polyphenols with powerful antioxidant properties including oligomeric procyanidins (OPCs) and flavonoid glycosides such as vitexin-2″- rhamnoside, which are included as some of its most important secondary metabolites.
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The bioactivities of these polyphenols have revealed extracts with extremely high levels of antioxidant activity, lending mainly towards their anti-atherogenic and cardioprotective effects.
Furthermore, Hawthorn bark extract has been shown to exert antioxidant effects by activating nuclear factor-2 (Nrf2)-like pathways, while increasing messenger ribonucleic acid (mRNA) and protein levels of several Nrf2-dependent genes in vitro.
The wide range of cardiovascular studies documented on Hawthorn point to its multivalent bioactivity and cardioprotective effects, which are mainly linked to its rich polyphenolic content. Numerous experimental and clinical studies using Hawthorn standardized for its polyphenolic content have demonstrated efficacy for cardiovascular conditions ranging from angina, hypertension, myocardial insufficiency, mild arrhythmias, and atherosclerosis through a variety of mechanisms including:
A 2008 meta-analysis of randomized, double-blind, placebo-controlled trials established the effectiveness of standard Hawthorn (leaf, berry, and/or flower) in the treatment of chronic heart failure when given over a range of three to six weeks. . In most of the included studies, Hawthorn was used as an adjunct to conventional drug treatment, and stronger effects of Hawthorn were noted in those with more severe underlying conditions. The analysis also found that Hawthorn showed an excellent safety profile and that any adverse effects were infrequent, mild and short-lived.
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Hawthorn extract has also shown positive effects on endothelial dysfunction, partly by mediating endothelial calcium signaling and thus protecting against endothelial hyperpermeability, which is essential in the formation of edema and inflammatory processes associated with heart failure.
Another aspect of Hawthorn’s cardioprotective properties is its influence on lowering blood cholesterol and its possible role in preventing the development of cardiovascular disease and, specifically, atherosclerosis. Several mechanisms of action have been proposed, and hawthorn berry infusions have been shown to reduce total cholesterol as well as all cholesterol fractions (VLDL, LDL, HDL) by increasing liver cholesterol uptake and degradation and reducing synthesis in animal models.
Furthermore, a double-blind trial using hawthorn leaf and flower extract over six months found that it significantly reduced plasma levels of neutrophil elastase (an important enzyme involved in the development and progression of atherosclerosis) in diabetics with chronic coronary heart disease compared with placebo. also significantly lowers LDL cholesterol levels.
In conclusion, the many effects of Hawthorn demonstrated from preclinical and clinical data have revealed a safe and effective cardioprotective plant that can improve cardiac performance in patients with mild to moderate heart failure, while also protecting against cardiovascular dysfunction more general. The presence of strong antioxidant polyphenolics in Hawthorn appears to be mainly responsible for mitigating the damage within the cardiovascular system, helping to alleviate the disease burden of patients with cardiac complaints, and ultimately leading to meaningful improvements in their quality of life.
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This medicinal herb is known to be one of the greatest natural agents for improving cardiovascular function. Hawthorn is approved as a cardiovascular aid by the Commission E- an important branch of the German government that studies and approves natural therapies (1, 2).
It is widely used in Europe to improve the circulatory system, treat angina, high blood pressure, cardiac arrhythmia and congestive heart failure. It is renowned for its ability to strengthen the heart and blood vessels and restore healthy muscular tone to the heart wall.
Hawthorn berries are loaded with a wide variety of powerful antioxidant nutrients. Antioxidants neutralize free radicals and reduce oxidative stress and tissue damage in the body. The unique combination of antioxidants found in Hawthorn comes from a group of phytonutrients (3). These include tannin, flavonoids, proanthocyanidins and phenolic acids. The standardization of hawthorn products is based on the general content of flavonoids (2.2%) and proanthocyanidins (18.75%).
Hawthorn berries have been well studied in individuals with congestive heart failure (4, 5). Five of the six large studies conducted found dramatic improvements in symptoms (such as shortness of breath and fatigue).
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One study showed that hawthorn (taken at 900mg per day) for 2 months was as effective as low doses of captopril (a leading heart medication) in improving common symptoms associated with congestive heart failure (6).
The unique antioxidant combination in Hawthorn creates a powerful vasodilating effect. It works to improve the endothelial function of blood vessels to the point where the vessel can open with less resistance. This allows more blood flow in working tissues and improves the use of oxygen. This is mainly due to the flavonoids rutin and vitexin together with the proanthocyanins (7, 8).
Hawthorn improves the metabolism of heart cells and improves the flow of electrolytes across the cardiac cells. This prevents or corrects heart rhythm abnormalities and strongly encourages a healthy cardiac rhythm.
Hawthorne contains flavones that improve the function of certain cardiac enzymes. This effect increases the contractile force of the heart, which effectively boosts stroke volume while increasing the heart’s tolerance to hypoxic conditions (9). It also improves the heart’s ability to create energy through anaerobic metabolism which improves the heart’s ability to withstand stress.
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Hawthorn also inhibits angiotensin converting enzyme (ACE). Elevated ACE causes an increase in angiotensin II and systemic vasoconstriction. This process raises blood pressure.
By modulating ACE levels, Hawthorn helps to normalize blood pressure and reduce stress on the cardiovascular system. The body usually takes two to four weeks to adjust to hawthorn and have lasting effects on blood pressure (10, 11, 12).
Hawthorn also helps protect joints with its unique blend of antioxidants. These phytonutrients prevent certain classes of free radicals known to damage tissue collagen leading to arthritic